Exam Code: ACRP-CP
Exam Name: ACRP Certified Professional Exam
Certification Provider: ACRP
Corresponding Certification: ACRP Certified Professional
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ACRP ACRP-CP Exam Syllabus Topics:

SectionWeightObjectives
Topic 1: Study Design and Conduct17%- Study implementation
  • 1. Study monitoring and oversight
  • 2. Site selection and activation
  • 3. Investigational product management
- Study planning
  • 1. Sample size and statistical considerations
  • 2. Study population and eligibility criteria
  • 3. Protocol development and amendments
Topic 2: Regulatory and Compliance Requirements17%- International standards
  • 1. Declaration of Helsinki
- ICH Guidelines
  • 1. E8 General Considerations for Clinical Trials
  • 2. E6(R2)/E6(R3) Good Clinical Practice
  • 3. E2A Expedited Reporting
  • 4. E11 Pediatric Trials
  • 5. E9 Statistical Principles
- Compliance procedures
  • 1. Regulatory submissions and approvals
  • 2. Audits and inspections
Topic 3: Clinical Study Operations15%- Project management
  • 1. Timeline and budget management
  • 2. Vendor and stakeholder management
- Site management
  • 1. Site personnel training and delegation
  • 2. Study documentation and record keeping
Topic 4: Professionalism and Ethical Practice15%- Professional standards
  • 1. Role responsibilities and boundaries
  • 2. Confidentiality and conflict of interest
- Continuous improvement
  • 1. Quality assurance and process improvement
  • 2. Professional development and education
Topic 5: Data Management and Informatics17%- Data collection
  • 1. Case report form design and completion
  • 2. Electronic data capture systems
- Data quality control
  • 1. Query management and resolution
  • 2. Data validation and cleaning
- Data reporting
  • 1. Database lock and data transfer
  • 2. Data integrity and security
Topic 6: Ethical and Participant Safety Considerations19%- Ethical principles
  • 1. Human subject protections and privacy
  • 2. Clinical equipoise and therapeutic misconception
- Safety monitoring and reporting
  • 1. Safety information evaluation and communication
  • 2. Adverse event identification and classification
- Clinical care and management of research participants
  • 1. Continuity of medical care
  • 2. Standard of care vs protocol requirements
  • 3. Informed consent development and review

ACRP Certified Professional Sample Questions:

1. Which of the following should be considered when implementing a risk-based monitoring plan?

A) 100% source document review is mandatory.
B) On-site monitoring frequency may change depending on the quality of the data.
C) Centralized monitoring must be incorporated in any trials.
D) Monitoring schedule must be pre-defined in the monitoring plan.


2. Access to study documentation for auditors and inspectors during an audit or inspection at a clinical trial site is the responsibility of the:

A) CRA
B) CRC
C) Sponsor
D) PI


3. In preparation for an upcoming site audit, whose responsibility is it to ensure study-related functions were conducted by qualified personnel?

A) CRA
B) CRC
C) Investigator
D) Sponsor


4. During a mid-study sponsor audit of a clinical trial, the auditor notices that all of the protocol-required subject drug dosing diaries were incomplete. The effect of this will be the inability to:

A) Evaluate study data.
B) Validate protocol endpoints.
C) Verify compliance with IP regimen.
D) Conduct safety analysis.


5. The site submitted all start-up documents for a study to the sponsor and the IRB/IEC. The site also has subjects identified for screening. What should happen FIRST?

A) Obtain IRB/IEC approval
B) Ship/receive IP
C) Verify subject eligibility
D) Schedule a site initiation visit


Solutions:

Question # 1
Answer: B
Question # 2
Answer: D
Question # 3
Answer: C
Question # 4
Answer: C
Question # 5
Answer: A

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